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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3A All Species: 36.06
Human Site: Y634 Identified Species: 52.89
UniProt: Q13472 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13472 NP_004609.1 1001 112372 Y634 L D E A L A Q Y F G N G T E L
Chimpanzee Pan troglodytes XP_511323 1001 112378 Y634 L D E A L A Q Y F G N G T E L
Rhesus Macaque Macaca mulatta XP_001095437 1001 112278 Y634 L D E A L A Q Y F G N G T E L
Dog Lupus familis XP_546656 989 110956 Y634 L D E A L S Q Y F G E G T E V
Cat Felis silvestris
Mouse Mus musculus O70157 1003 112340 Y634 L D E A L S Q Y L G E R T E M
Rat Rattus norvegicus XP_002742497 1001 111922 Y632 L D E A L S Q Y L G E R T E V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510142 1042 116269 Y677 L D E A L S Q Y F G E A A E V
Chicken Gallus gallus NP_001025807 1020 114626 Y636 L D Q A L A Q Y F G E A T E I
Frog Xenopus laevis NP_001085699 1022 114003 Y639 L D E A L S Q Y F G Q A A E A
Zebra Danio Brachydanio rerio XP_688695 998 112490 Y632 L D E A L S N Y L G P A Q E I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9NG98 1250 136119 T631 I S A R I N E T P A A N S A V
Honey Bee Apis mellifera XP_394050 958 109977 F602 D N A L A D Y F D E Q P T K I
Nematode Worm Caenorhab. elegans O61660 759 85420 H413 V Y E L V V R H F L A C V S Q
Sea Urchin Strong. purpuratus XP_782119 679 77025 I333 K L Y T Q G F I S Y P R T E T
Poplar Tree Populus trichocarpa XP_002307047 910 102138 W559 D D M G Y E L W K P N L R S L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201197 926 103389 E580 L M E H D M N E V S V G R K T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 87.7 N.A. 86.8 83.8 N.A. 72.8 73 70.9 66.5 N.A. 41.2 46.8 38.5 47
Protein Similarity: 100 99.6 97 91.1 N.A. 91.5 88.9 N.A. 80.5 82.9 81.8 80.3 N.A. 53.7 63.7 50.8 57
P-Site Identity: 100 100 100 80 N.A. 66.6 66.6 N.A. 66.6 73.3 66.6 53.3 N.A. 0 6.6 13.3 13.3
P-Site Similarity: 100 100 100 93.3 N.A. 80 80 N.A. 80 86.6 73.3 66.6 N.A. 33.3 33.3 40 13.3
Percent
Protein Identity: 40 N.A. N.A. 38.8 N.A. N.A.
Protein Similarity: 56.3 N.A. N.A. 54.5 N.A. N.A.
P-Site Identity: 20 N.A. N.A. 20 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 13 63 7 25 0 0 0 7 13 25 13 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % C
% Asp: 13 69 0 0 7 7 0 0 7 0 0 0 0 0 0 % D
% Glu: 0 0 69 0 0 7 7 7 0 7 32 0 0 69 0 % E
% Phe: 0 0 0 0 0 0 7 7 50 0 0 0 0 0 0 % F
% Gly: 0 0 0 7 0 7 0 0 0 63 0 32 0 0 0 % G
% His: 0 0 0 7 0 0 0 7 0 0 0 0 0 0 0 % H
% Ile: 7 0 0 0 7 0 0 7 0 0 0 0 0 0 19 % I
% Lys: 7 0 0 0 0 0 0 0 7 0 0 0 0 13 0 % K
% Leu: 69 7 0 13 63 0 7 0 19 7 0 7 0 0 25 % L
% Met: 0 7 7 0 0 7 0 0 0 0 0 0 0 0 7 % M
% Asn: 0 7 0 0 0 7 13 0 0 0 25 7 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 7 7 13 7 0 0 0 % P
% Gln: 0 0 7 0 7 0 57 0 0 0 13 0 7 0 7 % Q
% Arg: 0 0 0 7 0 0 7 0 0 0 0 19 13 0 0 % R
% Ser: 0 7 0 0 0 38 0 0 7 7 0 0 7 13 0 % S
% Thr: 0 0 0 7 0 0 0 7 0 0 0 0 57 0 13 % T
% Val: 7 0 0 0 7 7 0 0 7 0 7 0 7 0 25 % V
% Trp: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % W
% Tyr: 0 7 7 0 7 0 7 63 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _